What Not to Take with Stinging Nettle?

WrittenbyLuat Duong
Last updated

Stinging nettle (Urtica dioica) is a herbaceous plant that has been used for centuries in traditional medicine for various purposes, such as treating arthritis, allergies, and urinary tract infections. While it offers potential health benefits, it's crucial to be aware of the substances and medications that should not be taken with stinging nettle to avoid potential interactions or adverse effects.

What Not to Take with Stinging Nettle?

When consuming stinging nettle supplements or extracts, it's essential to avoid or exercise caution with the following substances:

  • Blood thinners (e.g., warfarin, aspirin)
  • Diuretics (water pills)
  • Antidepressants (e.g., lithium, SSRIs)
  • Non-steroidal anti-inflammatory drugs (NSAIDs)
  • Diabetes medications
  • Potassium-sparing diuretics

Blood Thinners

Stinging nettle may increase the risk of bleeding when combined with blood-thinning medications like warfarin or aspirin. This is because nettle contains compounds that may have anti-coagulant properties, which could potentially amplify the effects of blood thinners, leading to an increased risk of bruising or excessive bleeding.


Stinging nettle has mild diuretic properties, meaning it can promote increased urination and fluid loss. When combined with prescription diuretics (water pills), the effects may be amplified, potentially leading to dehydration, electrolyte imbalances, or excessive fluid loss.


Some research suggests that stinging nettle may interact with certain antidepressant medications, particularly lithium and selective serotonin reuptake inhibitors (SSRIs). These interactions could potentially alter the effectiveness of the medications or increase the risk of side effects.

Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Stinging nettle and NSAIDs (e.g., ibuprofen, naproxen) share anti-inflammatory properties. While the interactions are not well-documented, combining these substances could potentially increase the risk of gastrointestinal side effects, such as stomach upset or ulceration.

Diabetes Medications

There is some evidence that stinging nettle may have an impact on blood sugar levels, although the exact mechanisms are not fully understood. As a precaution, individuals taking medications for diabetes should consult with their healthcare provider before using nettle supplements, as they may interact with or affect the effectiveness of diabetes medications.

Potassium-sparing Diuretics

Stinging nettle is a rich source of potassium. When combined with potassium-sparing diuretics (medications that help the body retain potassium), there is a potential risk of developing hyperkalemia (high potassium levels), which can be dangerous in certain individuals, particularly those with kidney problems.

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General Precautions and Considerations

In addition to potential interactions with specific medications, there are some general precautions to consider when using stinging nettle supplements:

Dosage and Duration

It's essential to follow recommended dosages and not exceed the maximum daily intake, as high doses of stinging nettle may increase the risk of side effects. Additionally, prolonged use without medical supervision is not recommended, as the long-term effects of nettle consumption are not fully understood.

Allergy Risks

Individuals with known allergies to plants in the Urticaceae family (which includes stinging nettle) should avoid consuming or handling nettle, as it may trigger an allergic reaction.

Pregnancy and Breastfeeding

Stinging nettle is not recommended for pregnant or breastfeeding women due to a lack of sufficient research on its safety during these critical periods. It's generally advisable to exercise caution and avoid its use unless under the guidance of a qualified healthcare professional.

Consulting a Healthcare Professional

Before incorporating stinging nettle supplements into your routine, especially if you are taking any medications or have underlying medical conditions, it's crucial to consult with a qualified healthcare professional, such as a doctor, herbalist, or pharmacist. They can evaluate your individual health status, medication use, and potential risks or contraindications associated with stinging nettle consumption.

By being aware of the substances and medications that should not be taken with stinging nettle and exercising caution when using this herb, you can ensure its safe and appropriate use while minimizing potential interactions or adverse effects.

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Luat Duong

Luat Duong is a Copenhagen-based writer and content strategist specializing in hair loss and health. His work has been featured in MyHealthGuide, The Right Hairstyles, and Woman's Era. He is a graduate of Vaasa University. You can connect with him on LinkedIn.