If you're battling hair loss due to DHT (dihydrotestosterone), using a DHT-blocking serum can be a game-changer. These serums are specially formulated to target and block DHT, a hormone responsible for shrinking hair follicles and leading to hair thinning and loss.
By incorporating ingredients like saw palmetto, caffeine, and pumpkin seed oil, these serums can help strengthen hair follicles, stimulate regrowth, and support healthier, thicker hair.
In this guide, we’ve highlighted the best and most proven DHT-blocking serums, offering you top-tier options that are both effective and easy to incorporate into your daily routine.
Whether you're just starting to notice hair thinning or looking for ways to prevent further loss, these serums can be key to a healthier scalp and longer-lasting hair growth.
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How does DHT-blocking serum work?
DHT-blocking serums work by inhibiting the production of dihydrotestosterone (DHT), a hormone linked to hair loss. These serums contain natural ingredients that block the enzyme 5-alpha reductase, which is responsible for converting testosterone into DHT.
"DHT-blocking serums generally work by blocking the enzyme 5-alpha reductase, which is responsible for converting testosterone into DHT, that leads to preventing hair loss and promoting hair growth," explains Dr. Nicole Levine MD.
DHT binds to hair follicle receptors, causing them to shrink and stop producing hair over time. By reducing DHT levels, these serums slow the miniaturization of hair follicles, promoting healthier hair growth.
While they may not regrow lost hair, they help preserve existing hair and slow thinning. Visible effects can take a few months, but consistent use can improve hair thickness and health.
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Top DHT blocking serums
🔹 Best for Scalp Health: PURA D'OR Scalp Therapy Energizing Scalp Serum – Promotes scalp circulation and helps block DHT for healthier hair.
🔹 Best for Repair: MDhair Restore Serum – A potent formula designed to restore thinning hair by blocking DHT and nourishing follicles.
🔹 Best for Immediate Results: FOLIGAIN DHT Blocker Serum with 12% Trichogen – Targets DHT while delivering vital nutrients for hair regrowth.
🔹 Best for Biotin Infusion: Guyology Labs Biotin Hair Growth Serum – Combines biotin and DHT-blocking properties to enhance hair growth.
🔹 Best for Natural Ingredients: Re-Grow Anti Hair Loss & Rapid Growth Serum with Natural DHT Blocker – Uses plant-based ingredients to combat hair thinning.
🔹 Best for Maximum Growth: Propidren by Hairgenics Hair Growth Serum – A dual-action serum with DHT blockers and hair growth boosters.
🔹 Best for Volume: Ultrax Labs Hair Plush Serum – Boosts hair thickness while blocking DHT for fuller, more vibrant hair.
1. PURA D'OR Scalp Therapy Energizing Scalp Serum
Unleash the power of an exotic concoction of extracts and nutrients with the PURA D'OR Scalp Therapy Energizing Scalp Serum.
It's no ordinary serum - it’s a potent elixir that transforms your hair from the root to the tip, reducing thinning and enhancing thickness.
Key ingredients such as coffee extract, catalase, and cayenne invigorate the scalp and enrich the roots, resulting in healthier, stronger hair.
Moreover, the blend of amla, tea Tree, kahai seed, sacha inchi seed, and bilberry penetrates the scalp with ease, bringing forth lush, healthy strands.
The serum also boasts potent DHT blockers and an Apple Stem Cell formula that combats scalp acne and promotes stronger hair.
This formula aims to support existing hair and may help in maintaining hair density. Witness your hair's transformation with every use.
2. MDhair Restore Serum
The MDhair Restore Serum steps in as a powerful hair ally, packed with DHT blockers that stimulate and strengthen hair follicles. But that's not all.
The serum's unique formula features biomimetic copper peptides, saw palmetto extract, panax ginseng root, rosemary leaf oil, hydrolyzed rice, and oat proteins, biotin, and vitamin B5.
This potent blend does more than just hinder testosterone's conversion to DHT; it elevates scalp health and boosts hair density.
Natural ingredients in this serum aim to support your hair follicles, contributing to the appearance of thicker, healthier hair.
3. FOLIGAIN DHT Blocker Serum with 12% Trichogen
FOLIGAIN's DHT Blocker Serum with 12% Trichogen stands tall as a champion in hair care. This potent serum caters to men and women grappling with thinning hair, offering a solution that doesn't just promise but delivers.
With a formulation that effectively blocks DHT, this serum halts hair loss and spurs vigorous natural hair growth.
The power-packed Trichogen nutrient complex, coupled with Acetyl Tyrosine, panax ginseng root extract, biotin, and soy protein, forms an unparalleled blend that reinforces hair follicles, enhances scalp health, and conditions hair for natural growth.
Acetyl Tyrosine acts as a hair growth stimulant, skin cell fortifier, and a vital player in DHT inhibition.
Free from harsh parabens, sulfates, and phthalates, this serum is gentle on your scalp while imparting powerful results.
With FOLIGAIN's DHT Blocker Serum, experience an ethically sound and effective hair care solution that rejuvenates your scalp and revitalizes your hair.
4. Guyology labs Biotin Hair Growth Serum
With a mission to revitalize hair growth, Guyology Labs presents their Biotin Hair Growth Serum.
This serum boasts clinically proven natural growth ingredients that invigorate hair growth for fuller, thicker, and stronger hair within just three months.
The proprietary formula is a potent hair root stimulator growth serum that targets DHT - one of the primary hormones responsible for hair loss.
By blocking DHT, it reduces hair fall, loss, and shedding, stimulating new hair growth and reinforcing existing follicles.
This serum is power-packed with effective DHT blockers like saw palmetto extract biotin, and vitamin E for thicker, stronger hair, and caffeine and rosemary for a stimulated healthy scalp.
It is quick and easy to apply with its non-greasy formula that swiftly penetrates the hair shaft and scalp. This creates strength from within to catalyze new growth, improve hair density, and promote regrowth.
5. Re-Grow Anti Hair loss & Rapid Growth Serum With Natural DHT Blocker
The Re-Grow Anti Hair Loss Serum is a potent blend designed to combat hair loss.
Its unique formula blocks DHT, a primary cause of hair thinning, thereby stimulating dormant hair follicles on the scalp for rapid growth.
With its scientifically-proven DHT blockers, it effectively stops hair loss and promotes hair regrowth in both men and women, improving hair density.
Key ingredients like Saw Palmetto prevent DHT production, while biotin strengthens brittle hair and encourages the growth of healthy hair and skin cells.
The serum's unique blend of active ingredients creates a follicle-boosting effect that nurtures natural, healthy hair growth. It thickens fine hair, reduces hair loss, and balances an oily scalp by restoring nutrients to hair follicles.
Consistent usage over three months will yield the best results, all backed by a 100% money-back guarantee for a risk-free trial.
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6. Propidren by Hairgenics Hair Growth Serum
Provided by Hairgenics is a revolutionary hair growth serum specially formulated to address hair loss caused by DHT.
This serum works by directly delivering essential nutrients to nourish the scalp, hair, and hair follicles, naturally promoting follicular growth and hair thickening.
With just two daily applications of 1ml, it effectively blocks DHT's adverse effects, energizing the scalp to produce stronger, thicker hair.
The unique composition of Propidren includes natural ingredients known for their DHT-inhibiting properties, targeting DHT production at the hair follicles.
This serum is particularly beneficial as we age and experience increased DHT levels leading to hair thinning and loss.
It offers a dual-action solution when combined with Propidren supplements, providing an intensive, systemic, and topical treatment against hair loss.
7. Ultrax Labs Hair Plush Serum
This innovative hair serum by Ultrax Labs stands out with its unique caffeine-infused formula.
It's an advanced hair treatment that supports a healthy hair growth cycle while minimizing DHT's effects on your hair follicles.
The Hair Plush serum is designed to stimulate the scalp and invigorate hair follicles directly, thanks to its unique blend of ingredients.
Its key ingredient, caffeine, extends the life cycle of hair follicles, encouraging healthier, thicker hair. In addition to blocking DHT, the formula is also enriched with Hydrolyzed Keratin, which can increase the thickness of your individual hair strands for a fuller look.
Notably, the serum is safe for everyday use and for all hair types. Its formula is hypoallergenic, non-irritating, and free of harsh chemicals, making it a great option for those with sensitive scalps or who prefer gentler hair care products.
Are there any side effects of using DHT-blocking serums?
While DHT-blocking serums are generally considered safe and are well-tolerated by most people, they can sometimes cause side effects. These can range from mild to moderate and can include scalp irritation, redness, and itching. Some users may also experience increased hair shedding initially as the hair follicles transition from a resting phase to a growing phase.
Furthermore, it's important to remember that everyone's skin and hair are different, so what works well for one person might not work as well for another.
As with any new product, it's a good idea to test a small amount on your skin first to check for any adverse reactions.
It's always wise to consult a healthcare professional or a dermatologist if you have any concerns or experience ongoing discomfort.
Read this: 15 Best Hair Growth Serums for Superior Hair Growth (2025)
An effective and safer alternative to dht blocking serums
Bio-Pilixin Activation Serum is a standout in the hair care market, offering a safer, plant-powered alternative to traditional DHT-blocking serums.
This potent formula addresses hair loss effectively while encouraging new hair growth, providing an excellent solution for those experiencing brittle and thinning hair, rejuvenating both your hair and scalp.
Bio Pilixin features Capilia Longa, a derivative of Curcuma longa stem cells.
This power-packed ingredient has demonstrated exceptional results in minimizing hair loss and enhancing hair density.
The serum also includes Niacinamide, known to boost sustained hair growth by enhancing scalp blood circulation and safeguarding hair follicles from damage.
One of the distinguishing ingredients in Bio Pilixin's formula is Vanillyl Butyl Ether, a mild warming agent that elevates scalp circulation.
This improvement in circulation ensures optimal delivery of nutrients and oxygen to hair follicles, which is crucial for healthy hair growth.
Suitable for both men and women, Bio-Pilixin leverages innovative, plant-powered ingredients to help combat hair loss and improve hair density.
This product's effectiveness has been backed by numerous positive user testimonials and the assurance of a 150 days money-back guarantee, reflecting the brand's confidence in their product's performance.
How long does it typically take to see results from using DHT-blocking serums?
"DHT blockers are absorbed into the body quickly and start reducing DHT levels almost immediately once they're active. It typically takes 3 months to start seeing noticeable results," explains Dr. Nicole Levine MD.
While the serums begin working quickly to inhibit DHT production, visible improvements in hair thickness and growth usually become evident after about three months of consistent use.
Conclusion
DHT-blocking serums have become a promising solution for those dealing with hair loss and thinning. By using scientifically-backed formulas with potent natural ingredients, these serums effectively reduce hair loss by neutralizing DHT, the primary cause of hair damage.
The market offers a variety of effective DHT-blocking serums, including popular options like PURA D'OR, MDhair, FOLIGAIN, Guyology Labs, Re-Grow, and Propidren by Hairgenics. The Bio-Pilixin Serum stands out as a plant-powered alternative.
Consistency is crucial when using these products. Complementing your routine with ingredients like pumpkin seed oil and maintaining a balanced diet rich in nutrients can enhance hair health.
FAQs
Can I use DHT-blocking serums on curly hair?
Yes, you can use DHT-blocking serums on curly hair. The serum targets hair loss by blocking DHT on the scalp, not the texture of the hair itself. It will not interfere with your natural curls.
Will DHT-blocking serums straighten my curly hair?
No, DHT-blocking serums will not straighten your curly hair. These serums focus on preventing hair loss or promoting regrowth by blocking DHT, but they do not affect the natural curl pattern of your hair.
What should I look for in a curly hair oil/serum when using a DHT-blocking serum?
When using a DHT-blocking serum with curly hair, look for oils or serums that:
- Moisturize and hydrate: Ingredients like argan oil, jojoba oil, or shea butter help keep curls hydrated and frizz-free.
- Enhance curl definition: Look for products that define curls without weighing them down.
- Non-comedogenic: Ensure the serum doesn't clog pores on your scalp, which can hinder hair growth.
- Gentle and lightweight: Curly hair can get weighed down easily, so opt for lightweight formulations to keep curls bouncy.
Is DHT-blocking serum effective for both men and women?
Yes, DHT-blocking serums are effective for both men and women. They help treat androgenetic alopecia (hair thinning or loss caused by DHT) in both genders. Men may use them for male pattern baldness, while women can use them for thinning or hormonal-related hair loss.
References:
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171668/
- https://www.sciencedirect.com/science/article/pii/S0753332221000329
