What Medications Cause Curly Hair? Understanding Hair Changes

Medically reviewedby Dr. Bilal Khan M.B.B.S.
WrittenbyDr. Edna Skopljak, M.D.
Last updated

Dr. Bilal Khan M.B.B.S earned his medical doctorate at Sindh Medical College, Jinnah Sindh Medical University in Karachi, Pakistan. In September 2023, he successfully passed the United States Medical Licensing Examination (USMLE), achieving certification to practice medicine internationally. Read more...

While genetics play a significant role in determining your hair's natural texture, certain medications can also cause changes in hair texture, including making it curly. In this article, we will explore what medications can cause curly hair, understand the reasons behind these changes, and provide tips on managing and caring for your curly hair.

Table of content
1. What medications cause curly hair
2. Why do some medications cause curly hair?
3. Managing and caring for curly hair
4. Consulting your doctor

What medications cause curly hair

Several medications have been reported to cause hair texture changes, including curliness. Some of these medications include:

  • Retinoids: Used in acne and wrinkle treatments, retinoids have been associated with causing hair to become curlier after two months to a year of use1.
  • Hydroxychloroquine (Plaquenil): Although not listed in the prescribing information, some people have reported curling of hair when taking this medication2.
  • Other medications: Hair texture changes can also be caused by various medications, including contraceptives, antidepressants, and ibuprofen5.
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Why do some medications cause curly hair?

Changes in hair texture can be attributed to medications affecting the epidermal growth factor receptor (EGFR) or other factors that influence hair growth and development. However, the exact mechanisms through which medications cause curly hair remain unclear, and further research is needed to fully understand this phenomenon4.

Managing and caring for curly hair

If you notice that your hair has become curlier as a result of medication, there are several ways to manage and care for your new hair texture:

  • Choose the right shampoo and conditioner: Look for products specifically designed for curly hair, containing natural or essential oils like coconut oil, jojoba oil, sunflower oil, and avocado oil10.
  • Avoid harsh chemicals: Steer clear of products containing sulfates, silicones, and parabens, which can strip the hair of its natural oils and cause dryness and frizz.
  • Use gentle styling techniques: Avoid using heat styling tools, as they can damage the hair and cause breakage. Instead, opt for gentle methods like air drying and using a wide-tooth comb to detangle your curls.
  • Moisturize: Keep your hair well-hydrated by using leave-in conditioners and deep conditioning treatments specifically designed for curly hair.
  • Trim regularly: Schedule regular trims to remove split ends and maintain healthy hair growth.

Consulting your doctor

If you notice significant changes in your hair texture, it is crucial to consult your doctor. They can determine if the change is a side effect of a medication you are taking, help you understand the potential reasons behind the change, and suggest possible solutions or alternative medications if necessary4.

In conclusion, while several medications can cause curly hair, it is essential to understand the potential reasons behind these changes and take the necessary steps to manage and care for your hair. If you believe that your hair texture change is a result of a medication you are taking, consult your doctor for guidance and support.

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Dr. Edna Skopljak, M.D.

About the Writer

Edna Skopljak, MD — University of Ljubljana, Faculty of Medicine

Edna Skopljak, MD is a clinical doctor at the University Medical Center Ljubljana and a PhD candidate in Biomedicine at the University of Ljubljana. She combines clinical work with research and medical editing, bringing a clear, evidence-based lens to patient education. Previously, she held roles in the pharmaceutical sector (product management and chief medical officer) and served as a medical production editor for the journal Biomolecules and Biomedicine.

Dr. Skopljak’s publications span clinical topics, including urology and orthopedics. She has co-authored work affiliated with the Department of Orthopedic Surgery at University Medical Centre Ljubljana. She trained in medicine with early clinical experience in Slovenia, reflecting a long-standing focus on practical, patient-facing care.

She strictly follows our Editorial Standards: All medical statements are grounded in authoritative guidelines, FDA labels, and peer-reviewed studies, with clear distinction between approved treatments and adjunctive options.