Where Does the Hair Loss Gene Come From: Tracing the Hereditary Roots

WrittenbyDr. Edna Skopljak, M.D.
Last updated

For many people, hereditary hair loss runs in the family. The genetic factors that cause this common condition are passed down from parents to children through specific changes in our DNA.

Table of content
1. Where does the hair loss gene come from?

Where does the hair loss gene come from?

The two main types of hereditary hair loss - androgenetic alopecia (male/female pattern baldness) and alopecia areata - are linked to alleles (variants) on different chromosomes inherited from either parent.

Androgenetic Alopecia

This pattern baldness is influenced by genes on the X chromosome. It arises from genetic variations in the structure of androgen receptors in hair follicles passed on via X alleles from either parent. Men inherit their single X chromosome from their mother.

Alopecia Areata

This autoimmune type of hair loss is associated with genes on chromosome 6p21 involving immune pathway functioning. It can be inherited as an autosomal dominant trait from either the maternal or paternal genome.

Gene Expression

External factors like DHT hormone levels and immune dysfunction activate the expression of these inherited genetic predispositions, which then manifest as predictable hair loss symptoms.

Family History Patterns

While the specific implicated genes may differ, inheriting balding alleles linked to chromosomes X or 6 from one's parents raises the likelihood of inheriting certain hair loss conditions in a genetically dominant manner.

Advanced Genetic Testing

New technologies like DNA hair follicle analysis can reveal the exact gene variants present for personalized treatment based on underlying genetic and lifestyle factors influencing expression.

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Dr. Edna Skopljak, M.D.

About the Writer

Edna Skopljak, MD — University of Ljubljana, Faculty of Medicine

Edna Skopljak, MD is a clinical doctor at the University Medical Center Ljubljana and a PhD candidate in Biomedicine at the University of Ljubljana. She combines clinical work with research and medical editing, bringing a clear, evidence-based lens to patient education. Previously, she held roles in the pharmaceutical sector (product management and chief medical officer) and served as a medical production editor for the journal Biomolecules and Biomedicine.

Dr. Skopljak’s publications span clinical topics, including urology and orthopedics. She has co-authored work affiliated with the Department of Orthopedic Surgery at University Medical Centre Ljubljana. She trained in medicine with early clinical experience in Slovenia, reflecting a long-standing focus on practical, patient-facing care.

She strictly follows our Editorial Standards: All medical statements are grounded in authoritative guidelines, FDA labels, and peer-reviewed studies, with clear distinction between approved treatments and adjunctive options.