Does LDN Cause Hair Loss? Low Dose Naltrexone and Hair Health

Written by Our Editorial Team
Last updated

In the realm of healthcare and wellness, the use of low-dose naltrexone (LDN) has gained significant attention in recent years due to its potential therapeutic benefits for various medical conditions. As with any medication, however, the question of potential side effects, including hair loss, often arises. In this comprehensive article, we will delve into the relationship between LDN and hair loss, providing a thorough analysis to help you make an informed decision about your health and well-being.

Does LDN Cause Hair Loss?

While the potential connection between low-dose naltrexone (LDN) and hair loss has been a topic of discussion, the existing evidence is mixed, and the relationship is not entirely clear. Some individuals have reported experiencing hair loss while taking LDN, but it is essential to understand the nuances and consider other factors that may contribute to this issue.

Understanding Low-Dose Naltrexone (LDN)

Low-dose naltrexone is a medication that has been used off-label to treat a variety of conditions, including autoimmune disorders, chronic pain, and certain neurological conditions. It works by modulating the body's endogenous opioid system, which plays a crucial role in regulating the immune response and pain perception.

Mechanism of Action

At low doses (typically between 1-5 mg), naltrexone acts as an antagonist to opioid receptors, temporarily blocking them, which in turn leads to an increase in the production of endorphins and other beneficial molecules within the body.

Potential Link Between LDN and Hair Loss

The potential connection between LDN and hair loss can be attributed to a few key factors:

Autoimmune Conditions

Some of the medical conditions for which LDN is prescribed, such as autoimmune disorders, can themselves be associated with hair loss. In these cases, the hair loss may not be directly caused by LDN, but rather a result of the underlying condition.

Stress and Hormonal Changes

The use of LDN can sometimes lead to temporary changes in hormone levels, which may, in turn, contribute to increased hair shedding or thinning, particularly in individuals who are more sensitive to hormonal fluctuations.

Individual Variation

As with any medication or treatment, the response to LDN can vary greatly from person to person. What may cause hair loss in one individual may not have the same effect on another, depending on various factors, such as genetics, overall health, and individual sensitivity.

Factors to Consider

When evaluating the potential impact of LDN on hair loss, it's essential to consider the following factors:

Underlying Conditions

Individuals with pre-existing autoimmune disorders, thyroid imbalances, or other medical conditions that can contribute to hair loss may be more susceptible to experiencing this side effect while taking LDN.

Dose and Duration of Use

The dosage of LDN and the duration of use may play a role in the likelihood of experiencing hair loss. Higher doses or prolonged use may increase the risk, while lower doses or shorter-term use may be less likely to cause this side effect.

Timing of Hair Loss

If hair loss occurs shortly after starting LDN, it may be more directly related to the medication. However, if hair loss occurs months or years into treatment, it may be due to other factors unrelated to LDN.

Addressing Hair Loss While Taking LDN

If you experience hair loss while taking LDN, there are several steps you can take to address the issue:

Consult with a Healthcare Provider

It's crucial to discuss the hair loss with your healthcare provider, who can help determine the underlying cause and provide appropriate guidance on managing the issue.

Consider Adjusting the Dosage

In some cases, adjusting the dosage of LDN or temporarily discontinuing the medication may help alleviate the hair loss. However, this should only be done under the supervision of a healthcare professional.

Incorporate Hair-Healthy Practices

Engaging in hair-nourishing practices, such as using gentle hair care products, minimizing heat styling, and incorporating scalp massages, can help support hair health and potentially mitigate the effects of hair loss.

Explore Supplementation

Certain supplements, such as biotin, iron, or other hair-supporting nutrients, may help strengthen and support hair growth, but it's essential to consult with a healthcare provider before starting any new supplement regimen.

Alternatives and Considerations

If you are concerned about the potential impact of LDN on your hair, you may want to explore the following alternatives and considerations:

Discuss Alternative Treatments

If hair loss is a significant concern, your healthcare provider may recommend exploring alternative treatment options that are less likely to cause this side effect.

Monitor Hair Health Closely

If you decide to continue taking LDN, be vigilant about monitoring your hair health and address any issues promptly with your healthcare provider.

Prioritize Overall Wellbeing

While hair loss can be distressing, it's important to remember that your overall health and wellbeing should be the primary focus. Work closely with your healthcare team to find the most suitable approach for your individual needs.


In conclusion, the relationship between low-dose naltrexone (LDN) and hair loss is not entirely clear-cut. While some individuals have reported experiencing hair loss while taking LDN, the evidence is mixed, and the underlying causes may be multifaceted, involving factors such as pre-existing medical conditions, hormonal changes, and individual sensitivity.

If you are taking LDN and have concerns about hair loss, it's essential to consult with your healthcare provider, who can help evaluate the potential causes and provide personalized guidance on managing the issue. By working closely with your medical team and incorporating hair-healthy practices, you can navigate this challenge and prioritize your overall health and wellbeing.

Remember, the decision to use LDN or any medication should be based on a thorough evaluation of the potential benefits and risks, taking into account your unique medical history and individual circumstances. With the right information and support, you can make an informed decision that aligns with your health goals and ensures the continued health and vitality of your hair.

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