Best 7 Eyelash Serums Without Prostaglandin Of 2024: Reviewed & Ranked

Medically reviewedby Dr. Amy Revene M.B.B.S.
WrittenbyLuat Duong
Last updated

Looking for the best eyelash serum without prostaglandin in 2024?

Discover our top 7 picks for eyelash serums that promise fuller, healthier lashes without the use of prostaglandins, ensuring your beauty routine is both safe and effective.

What is prostaglandin?

Prostaglandin, a group of lipid compounds, plays a hormone-like role in various tissues, significantly impacting lash growth serum formulations. They play critical roles in a wide range of physiological functions, including inflammation, blood flow, the formation of blood clots, and the induction of labor in pregnant women.

Expanding on this, prostaglandins are produced at sites of tissue damage or infection, triggering inflammation and pain, which is a critical consideration in the development of lash enhancing serum solutions.

In the context of eyelash serums, certain prostaglandins or their analogs are used to promote lash growth.

However, due to potential side effects like eye irritation, color changes, and unintended hair growth along the lash line, many opt for prostaglandin-free eyelash growth serums as a safer alternative for enhancing lash appearance.

Why you can trust Scandinavian Biolabs?
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7 best eyelash serums without prostaglandin

Here are the 7 best eyelash serums without prostaglandin:

  1. Scandinavian Biolabs Eyelash Growth Serum
  2. RevitaLash Cosmetics Advanced Eyelash Conditioner
  3. Maybelline Boosting Eyelash Serum
  4. Lancôme Lash Revitalizing Serum
  5. The Ordinary Lash and Brow Serum
  6. Vegamour Lash Serum
  7. Obagi Eyelash Enhancing Serum

1. Scandinavian Biolabs Eyelash Growth Serum

best eyelash serum without prostaglandin

Scandinavian Biolabs Eyelash Growth Serum leverages the Bio-Pilixin® formula to promote fuller-looking lashes by nourishing and protecting lash follicles. 

Featuring Capilia Longa for significant hair loss reduction and density improvement, biotin for hydration and breakage prevention, and an amino-acid blend to enhance hair strength, this serum offers visible results in 4 to 6 weeks. 

Dermatologically tested and crafted in Denmark, it's a safe and effective choice for those seeking natural lash enhancement.

Eyelash Growth Serum | 6 mL
Eyelash Growth Serum | 6 mL
Formulated to encourage fuller appearing lashes by helping to nourish follicles

2. RevitaLash Cosmetics Advanced Eyelash Conditioner

RevitaLash Cosmetics Advanced Eyelash Conditioner

The RevitaLash Advanced Eyelash Conditioner stands out among the best eyelash growth serums, impressing users with noticeable results.

After just a month of application, many report a noticeable improvement in lash length, often prompting questions about professional lash treatments. 

Its ease of use is another plus, with a fine brush tip that ensures precise application without excess product or discomfort.

It's highlighted for containing less prostaglandin, minimizing potential side effects while delivering fuller, shinier lashes thanks to its peptide-rich formula.

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3. Maybelline Boosting Eyelash Serum

Maybelline Boosting Eyelash Serum

The Maybelline Boosting Eyelash Serum stands out as the best budget-friendly option for those new to eyelash serums or looking for an effortless application. Its mascara-like bristled wand makes application intuitive, mirroring the familiar action of applying mascara. 

This serum enhances lash volume and promotes thicker, healthier lashes over time, thanks to its blend of arginine and pro-vitamin B5.

After ten weeks of consistent use, a significant improvement in lash volume and health was noticeable, making it an excellent choice for those seeking effective results without a hefty price tag.

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4. Lancôme Lash Revitalizing Serum

Lancôme Lash Revitalizing Serum

For those with sensitive eyes or skin conditions like eczema, the Lancôme Cils Booster Lash Revitalizing Serum offers a gentle yet potent formula. 

It's designed to be irritation-free, integrating seamlessly into nightly skincare routines without causing discomfort or adverse reactions.

This serum's fast-drying, fragrance-free formula ensures a hassle-free application, requiring just a single dip for both eyes. 

Users have reported noticeable enhancements in lash length and thickness, with a significant reduction in lash loss, making it a top contender for both effectiveness and sensitivity considerations.

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5. The Ordinary Lash and Brow Serum

The Ordinary Lash and Brow Serum

The Ordinary Lash and Brow Serum is a highly sought-after option for those looking to enhance their lashes and brows without the harsh effects of prostaglandins. Its affordability and gentle formula make it a favorite among shoppers. 

Featuring key ingredients like panthenol, biotinoyl tripeptide-1, acetyl tetrapeptide-3, and trifolium pratense flower extract, it aims to increase both density and thickness of lashes and brows. 

While the necessity for twice-daily application might seem demanding, the fast-drying nature of the serum and the promise of visible results in just four weeks make it a compelling choice for those committed to their beauty routines.

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6. Vegamour Lash Serum

Vegamour Lash Serum

Vegamour's GRO+ Advanced Lash Serum is distinguished by its inclusion of broad-spectrum CBD, mung bean, and red clover, components that contribute to a healthier lash line and foster natural lash growth.

Its vegan and cruelty-free credentials, coupled with a formula that's gentle on sensitive eye areas, make it a standout for those seeking ethical beauty solutions. 

Although it's not renowned for instant, dramatic outcomes, this lash enhancing serum promises gradual, natural enhancement, especially noticeable in the inner lashes after consistent use over a month.

For those prioritizing a gentle and sustainable method to achieve long lashes, Vegamour presents an appealing option, though patience is necessary for visible improvements.

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7. Obagi Eyelash Enhancing Serum

Obagi Eyelash Enhancing Serum

The Obagi Nu-Cil Eyelash Enhancing Serum offers a premium lash growth solution, utilizing the brand's proprietary NouriPlex Technology for significant lash enhancement.

This technology blends panthenol, biotin, sodium hyaluronate, and a unique lipid compound to effectively enhance lash growth. 

Despite its popularity, users should note its inclusion of dehydrolatanoprost, a prostaglandin-based lash serum ingredient, raising concerns similar to prescription options like Latisse.

Obagi's transparent warning about the possibility of permanent iris pigmentation changes and potential eyelid darkening is crucial to consider for anyone weighing the benefits against the risks of using such a potent formula.

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Why you should avoid prostaglandin?

You should avoid prostaglandins in eyelash serums due to potential side effects, including eye irritation, changes in iris color, eyelid skin darkening, and unwanted hair growth around the eyes. These side effects can be particularly concerning for individuals with sensitive eyes or skin.

Prostaglandins, while effective in promoting eyelash growth, can lead to a range of unintended consequences. For example, the change in iris color is often permanent, which can be a significant concern for many users. 

Additionally, the skin around the eyes may darken, a condition which might be reversible upon discontinuation of the product, but this is not always the case. Eye irritation and redness are also common, potentially leading to discomfort or a decrease in product usage. 

Given these concerns, individuals often search for prostaglandin-free lash growth serums as a safer route to achieve longer, thicker lashes without the adverse effects.

What should you consider before buying a lash serum?

thinning lashes, aloe barbadensis leaf juice and hyaluronic acid

Selecting the ideal lash serum involves careful consideration of ingredients, desired outcomes, and personal circumstances, such as pregnancy. Here's how to navigate these considerations effectively.

Key ingredients for effective lash growth

Opt for lash serums enriched with peptides, amino acids, and vitamins to directly nourish hair follicles for stronger and fuller lashes. Avoid those containing prostaglandins or their derivatives due to potential side effects like eyelid drooping and skin darkening.

Setting your lash enhancement goals

Define your lash goals—length, volume, or quick results—to select a serum tailored to your needs. Understanding the specific benefits and time frame for results can guide you to the ideal product.

Safety considerations for pregnant users

Pregnancy demands caution with beauty products, especially those containing hormonal substances like prostaglandins. Choose peptide- and vitamin-based serums for a safer alternative and consult a healthcare provider before use.


Navigating through the vast options of eyelash serums in 2024 reveals that achieving fuller, longer lashes without the risks associated with prostaglandins is more accessible than ever. 

From the natural formulations of Scandinavian Biolabs to the advanced peptide-rich solutions offered by RevitaLash Cosmetics, these serums stand out not just for their ability to promote lash growth, but also for their commitment to avoiding potential side effects linked with prostaglandin.  

As this guide wraps up, it's evident that the pursuit of beauty doesn't have to compromise safety. The highlighted serums exemplify how innovation and care in formulation can provide effective solutions for lash enhancement. 

For those ready to embark on their journey toward achieving their best lashes yet, exploring these top picks is a great starting point.

Each product, with its unique blend of ingredients and benefits, offers a pathway to not only achieving desired aesthetic goals, but doing so in a health-conscious manner. 


Are prostaglandin lash serums safe to use?

Prescription prostaglandin lash serums have been approved by the FDA and are generally considered safe. However, users should be aware of potential side effects such as eye irritation, dryness, and eyelid darkening, which may impact eye health.

Can prostaglandin in lash serums be harmful to the eyes?

Yes, prostaglandins in lash serums can cause negative effects like inflammation, irritation, redness, itchiness, and even swelling of the eyelids. Long-term use can lead to dry eyes and permanent darkening of the eyelid skin.

What are the side effects of prostaglandin in eyelash serums?

The side effects of prostaglandin in eyelash serums include eye irritation, dryness, redness, itchiness, swelling of the eyelids, and darkening of the eyelid skin. Users should weigh these potential risks before starting treatment.


Luat Duong

Luat Duong is a Copenhagen-based writer and content strategist specializing in hair loss and health. His work has been featured in MyHealthGuide, The Right Hairstyles, and Woman's Era. He is a graduate of Vaasa University. You can connect with him on LinkedIn.