Minoxidil 2 Vs 5: Which One Is Better For Female Hair Loss?

Medically reviewedby Dr. Amy Revene M.B.B.S.
WrittenbyLuat Duong
Last updated

Choosing the right Minoxidil concentration is crucial for effectively managing hair loss.

Whether you're considering Minoxidil 2% or 5%, understanding their differences can help you make an informed decision.

In this article, we'll delve into the benefits, side effects, and effectiveness of Minoxidil 2% versus 5%, providing you with all the information you need to choose the best option for your hair growth journey.

Let's explore how these two popular concentrations stack up against each other.

What is minoxidil?

minoxidil 2 vs 5

Minoxidil is an over-the-counter medication commonly used to help reduce hair loss and promote hair growth. Initially developed as a treatment for high blood pressure, it was discovered to have the side effect of stimulating hair growth. 

Today, it's available in topical solutions and foam preparations, in 2% and 5% concentrations, and is widely used to treat male and female pattern baldness. 

Types of minoxidil:

  1. Minoxidil solution: The solution form of Minoxidil is the original topical treatment for hair loss. It's applied directly to the scalp using a dropper and comes in both 2% and 5% concentrations. This liquid solution is often preferred by individuals with longer hair as it can be easier to apply to the scalp.
  2. Minoxidil foam: Introduced later, the foam version also comes in 5% concentration and is considered easier to apply and less messy than the solution. It's typically applied twice daily, just like the solution, and has been shown to be just as effective.
  3. Oral Minoxidil: Originally developed as a blood pressure medication, oral Minoxidil is not typically used for hair loss due to its potential for serious side effects. However, in some rare cases, under the careful supervision of a healthcare provider, low doses may be used off-label to treat hair loss.
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How does minoxidil work?

Minoxidil works by helping to prolong the growth phase of the hair follicles. It is a vasodilator, meaning it widens the blood vessels, which allows more oxygen, blood, and nutrients to reach the hair follicles. This may stimulate hair follicles that are in a resting state to move into an active growing state, leading to longer, thicker, and more robust hair growth.

Can women use minoxidil?

Yes, women can use Minoxidil for hair loss as demonstrated in various studies as well. The U.S. Food and Drug Administration (FDA) has approved the use of 2% topical Minoxidil for treating hair loss in women, and it's available over the counter. 

While the 5% concentration was initially only approved for use in men, research has shown it to be safe and more effective than the 2% solution in women as well.

Can women use 5% minoxidil?

Absolutely, women can use 5% Minoxidil. Research has consistently highlighted the effectiveness of 5% Minoxidil in promoting hair regrowth in women.

Initially, the FDA approval for 5% Minoxidil foam was exclusive to men since 2006, but the landscape changed in 2014 when it was also approved for use by women dealing with female pattern hair loss (FPHL).

A significant advantage of Minoxidil foam is its ease of application and its ability to efficiently penetrate the scalp, leading to improved results. 

Moreover, this form tends to cause less irritation compared to its liquid counterparts, making it a preferred choice for many.

Effectiveness of minoxidil 2 vs 5

The effectiveness of Minoxidil, whether in 2% or 5% concentration, has been the subject of numerous studies. 

One such 48-week study, involving 381 women dealing with female pattern hair loss, compared the impacts of these two strengths.

The women applied their assigned concentration of Minoxidil twice daily, and at the end of the study, results showed that both groups experienced an increase in hair regrowth and scalp coverage. 

However, the group using the 5% solution saw more pronounced results compared to the 2% group, which still notably outperformed the placebo group. 

Another six-month randomized clinical trial featured a comparison between the 5% Minoxidil foam and the 2% topical solution, with 113 women participating who were experiencing androgenetic alopecia. 

In this study, the 5% group applied the treatment once daily, while the 2% group used it twice daily. 

Researchers found no significant difference in hair count and target area hair width between the two groups by the end of the study. 

Interestingly, the study also found that women who used the 5% Minoxidil foam reported lower rates of intolerance than those who used the 2% solution. 

It remains uncertain whether this is due to the difference in formulations or the frequency of application (once daily vs. twice daily).

Side effects of minoxidil 2 vs 5

minoxidil 2 vs 5

Side effects with both 2% and 5% Minoxidil are relatively rare, but it's essential to consult with your dermatologist or healthcare provider before starting the treatment.

Interestingly, studies have produced conflicting results regarding side effects between the two concentrations. Some research suggests that users of the 5% Minoxidil foam experience less scalp itching or dandruff compared to the 2% Minoxidil solution users. 

This difference might be attributed to the frequency of application, with the 5% foam applied once daily, compared to twice daily for the 2% solution.

Contrastingly, the 48-week study highlighted an increased incidence of pruritus (itching), local irritation, and hypertrichosis (excessive hair growth) with the 5% topical Minoxidil compared to the 2% topical Minoxidil and the placebo group. 

This contrast in findings underscores the point that the effects and side effects of Minoxidil can vary considerably from person to person.

Common side effects associated with topical Minoxidil can include:

  • Scalp irritation, dermatitis, or rash at the application site.
  • Scalp itchiness or flaking.
  • A slight burning sensation.
  • Skin rash.
  • Risky for the fetus of a pregnant woman. 

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What’s the difference between minoxidil 2%, 5%, and 10%?

The main difference between Minoxidil 2%, 5%, and 10% is their concentration levels. Minoxidil 2% and 5% are approved for treating androgenetic alopecia, while the 10% concentration is not approved for hair loss treatment.

Here some other differences between Minoxidil 2% and Minoxidil 5%:


2% Minoxidil contains a lower concentration of the active ingredient, making it milder than the 5% version. 

It was initially the only approved concentration for women, while 5% Minoxidil contains a higher concentration, initially approved only for men.


5% Minoxidil has been found to be more effective in promoting hair regrowth than the 2% solution. 

However, individual responses may vary, and both concentrations have been shown to be more effective than placebo.

Application frequency

Typically, the 2% Minoxidil solution is applied twice daily, whereas the 5% foam is often used once daily. 

This could potentially influence the user's convenience and consistency in application.

Side effects

While side effects are rare for both concentrations, the 5% Minoxidil has been associated with a slightly higher incidence of side effects, such as scalp irritation and unwanted hair growth in areas other than the scalp. 

However, some studies suggest less irritation with the 5% foam compared to the 2% solution.

Minoxidil 2 vs 5: Which is better?

minoxidil 2 vs 5

Clinical trials suggest that 5% Minoxidil may lead to more pronounced hair regrowth. However, individual responses can differ, and some may find the lower-strength solution adequately effective. Moreover, the potential for experiencing side effects, although rare, may be slightly higher with the 5% strength.

Personal preference also plays a significant role. Do you prefer applying a liquid solution that may be easier to target specific areas, or do you favor a foam that might be quicker to absorb? 

Both have their advantages, and it might come down to a matter of which one suits your lifestyle and routine better.

Ultimately, whether 2% Minoxidil or 5% Minoxidil is "better" is a decision best made in consultation with a healthcare provider, taking into account your specific circumstances and hair loss condition.


Both 2% and 5% Minoxidil can be effective for treating hair loss in women. However, the 5% concentration tends to deliver more pronounced results, despite a slightly increased risk of minor side effects. 

Personal preference and lifestyle can also influence the choice between the liquid solution and the foam.

Before starting any hair loss treatment, it's crucial to consult a healthcare provider to better understand your specific circumstances and hair loss condition. 

Finding the right treatment may involve some trial and error, but staying consistent and patient with the process is key.

It's also important to remember that there are alternatives to Minoxidil. The Bio-Pilixin Serum by Scandinavian Biolabs, for example, provides an innovative blend of plant-derived compounds known to stimulate hair growth and overall hair health. 

This serum could be an intriguing alternative, especially considering the generous 150-day money-back guarantee offered, allowing for a risk-free trial.

No matter what treatment you choose, remember that the journey to better hair health is a marathon, not a sprint. Patience and consistency are your best allies in this journey.


Can I use Minoxidil if I'm pregnant or breastfeeding?

No, Minoxidil is not recommended for use if you are pregnant, planning to become pregnant, or breastfeeding. Minoxidil may be absorbed into the bloodstream and could potentially harm a baby.

Can I use Minoxidil 5% even if the 2% solution has been effective for me?

Yes, you can switch to the 5% solution even if the 2% has been effective. However, it's essential to monitor any potential side effects, as the higher concentration may increase the likelihood of minor side effects. Always consult with your healthcare provider before making any changes to your treatment regimen.

How long will it take to see results with Minoxidil?

Typically, it may take between 3 and 6 months of consistent use before seeing noticeable results with Minoxidil. Hair grows slowly, and patience is key.

If I stop using Minoxidil, will my hair fall out?

Yes, discontinuing Minoxidil treatment often leads to a reversal of any hair regrowth within several months. The medication requires continuous usage to maintain its effects.

Is the Bio-Pilixin Serum a suitable alternative to Minoxidil?

Yes, the Bio-Pilixin Serum could be an effective alternative to Minoxidil. It includes potent ingredients known to stimulate hair growth and comes with a 150-day money-back guarantee. However, as with any treatment, results may vary, and it's always a good idea to consult with your healthcare provider before starting new treatments.


The information we provide is not intended to mitigate, prevent, treat, cure or diagnose any disease or condition. If you have any concerns about your health, please consult your doctor.


    Luat Duong

    Luat Duong is a Copenhagen-based writer and content strategist specializing in hair loss and health. His work has been featured in MyHealthGuide, The Right Hairstyles, and Woman's Era. He is a graduate of Vaasa University. You can connect with him on LinkedIn.