DHT-blocking shampoos are a powerful tool in the fight against hair loss. Dihydrotestosterone (DHT) is a hormone linked to hair thinning and male and female pattern baldness.
By using shampoos formulated with natural DHT blockers like saw palmetto, pumpkin seed oil, and ketoconazole, you can help protect your hair follicles, reduce shedding, and promote healthier hair growth.
In this guide, we’ve compiled the 9 best DHT-blocking shampoos that effectively target DHT buildup, nourish the scalp, and support thicker, fuller hair.
Whether you’re experiencing early-stage thinning or want to prevent future hair loss, these shampoos are a must-have in your hair care routine.
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What is DHT?
DHT is a derivative of testosterone that binds to hair follicle receptors, causing them to shrink and eventually stop producing hair. This process results in male pattern baldness, also known as androgenetic alopecia, and can affect both men and women. DHT-blocking shampoos aim to prevent hair loss by reducing DHT levels in the scalp, thus promoting hair growth and maintaining hair density.
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Best DHT-Blocking Shampoos
These products has their own pros and cons, it's not ranked in any order.
🔹 Best Overall: Hims Thickening Shampoo – Formulated with saw palmetto to help reduce DHT and promote thicker hair.
🔹 Best for Early Hair Loss: Keeps Thickening Shampoo – Strengthens hair and supports scalp health for men experiencing thinning.
🔹 Best Natural Formula: PURA D’OR Original Gold Label Anti-Hair Thinning Shampoo – Organic ingredients, biotin, and DHT blockers.
🔹 Best for Regrowth Support: ProBliva DHT Blocker Hair Loss & Hair Re-Growth Shampoo – Infused with green tea and nettle extract.
🔹 Best 2-in-1 Treatment: Roman Finasteride & Minoxidil Topical – A prescription-based combo for maximum hair regrowth.
🔹 Best for Volume Boost: Pure Biology RevivaHair Shampoo – Keratin-infused for strengthening and thickening fine hair.
🔹 Best Clinically-Tested: Ultrax Labs Hair Surge Shampoo – Caffeine-powered formula to stimulate follicles.
🔹 Best Dermatologist-Recommended: Hairgenics Pronexa Regrowth Shampoo – Biotin and DHT blockers to reduce thinning.
🔹 Best Budget-Friendly: Cosmeceuticals Biotin Hair Loss Shampoo – Affordable yet effective for hair growth support.
1. Hims Thickening Shampoo
- Best for: Over-the-counter
- Key ingredients: Saw palmetto
- Prescription needed? No
Hims Thickening Shampoo is an affordable option that uses saw palmetto to block DHT, making it a popular choice for those looking for an over-the-counter solution.
2. Keeps Thickening Shampoo
- Best for: Subscription
- Key ingredients: Saw palmetto and caffeine
- Prescription needed? No
Keeps Thickening Shampoo offers a subscription service, making it convenient for those who want a consistent supply. The combination of saw palmetto and caffeine helps block DHT and promote hair growth.
3. PURA D’OR Original Gold Label Anti-Hair Thinning Shampoo
- Best for: Highly rated
- Key ingredients: Saw palmetto and nettle extract
- Prescription needed? No
PURA D’OR Original Gold Label Anti-Hair Thinning Shampoo is a highly rated option that uses saw palmetto and stinging nettle extract to block DHT effectively. It's a popular choice for those who want a top-rated shampoo with proven results.
4. ProBliva DHT Blocker Hair Loss & Hair Re-Growth Shampoo
- Best for: Sulfate-free
- Key ingredients: Kapilarine complex
- Prescription needed? No
ProBliva DHT Blocker Hair Loss & Hair Re-Growth Shampoo is a sulfate-free shampoo option that uses the kapilarine complex to block DHT and promote hair growth. It's ideal for those who want a shampoo without sulfates.
5. Roman Finasteride & Minoxidil Topical
- Best for: Topical treatment
- Key ingredients: Finasteride with minoxidil
- Prescription needed? Yes
Roman Finasteride & Minoxidil Topical is a topical treatment that combines finasteride with minoxidil, providing a powerful DHT-blocking solution. A prescription is needed for this treatment.
6. Pure Biology RevivaHair Shampoo
- Best for: Preventing hair loss, breakage, and thinning
- Key ingredients: Biotin, keratin, coconut oil, castor oil, Amino Kera NPNF Keratin Complex, Procapil
- Prescription needed? No
Pure Biology RevivaHair Shampoo is a great option to help prevent hair loss, breakage, and thinning caused by DHT. It contains natural ingredients such as biotin, keratin, coconut oil, castor oil, and more that work together to restore hair growth.
The Amino Kera NPNF Keratin Complex hydrates the scalp and hair follicles for better circulation and stronger, thicker hair. Procapil targets the main causes of alopecia to promote regrowth. It's gentle enough to use daily and is free from GMOs, cruelty, and parabens.
7. Ultrax Labs Hair Surge Shampoo
- Best for: Quick results
- Key ingredients: Saw palmetto, peppermint oil, caffeine, ketoconazole
- Prescription needed? No
Ultrax Labs Hair Surge Shampoo is a great splurge for those looking to block DHT. Its unique formulation of saw palmetto, peppermint oil, caffeine, and ketoconazole provides effective blocking of DHT to help reduce hair loss.
Reviews show that users saw effects in as little as a month or two, making it an ideal option for those looking to reduce their hair loss quickly. Plus, this shampoo is made without any animal products, making it a great option for those concerned about animal cruelty.
8. Hairgenics Pronexa Regrowth Shampoo
- Best for: Hair regrowth
- Key ingredients: Aloe vera, seaweed extracts, saw palmetto extract, biotin, collagen peptides, vitamin B5
- Prescription needed? No
Pronexa Regrowth Shampoo is a great choice for those looking to combat the effects of DHT in their hair. This shampoo has aloe vera and seaweed extracts to deeply moisturize the scalp, saw palmetto extract to stop DHT from working, biotin to strengthen weak hair, collagen peptides to help hair grow back, and vitamin B5 to help hair grow back.
Additionally, it's free of parabens, sulphates, gluten, vegan, cruelty, and color. Pronexa promises significant hair regrowth in just 60 days and advises using the product for up to 6 months for best results.
9. Cosmeceuticals Biotin Hair Loss Shampoo
- Best for: Multiple DHT blockers
- Key ingredients: Saw palmetto, biotin, argan oil
- Prescription needed? No
Cosmeceuticals Biotin Hair Loss Shampoo is an excellent choice for those looking for a DHT-blocking shampoo. It contains 14 different blockers, including saw palmetto and biotin, to help promote healthy hair growth.
The shampoo also contains nourishing argan oil and is safe for all hair types, including color-treated hair. Many reviewers said that using this product made their hair thicker, fuller, and less likely to fall out. Some reviewers, however, have found the scent to be strong and overpowering.
What are DHT-blocking shampoo side effects?
While DHT-blocking shampoos are generally considered safe, some people may experience side effects such as scalp irritation, dryness, itching, or flaking. Additionally, since DHT plays a role in regulating hair growth, blocking it may also potentially lead to hair loss or a decrease in hair density.
Read this guide for a more in-depth look at DHT-blocking shampoo side effects and DHT blocker side effects in general.
Considering the potential side effects of DHT blockers, we've got an alternative that'll work for you (or money-back!)
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What to look for in a DHT-blocking shampoo?
When searching for the best DHT-blocking shampoo, consider the following key ingredients, which have the most evidence supporting their DHT-blocking properties:
- Saw palmetto
- Finasteride and minoxidil
- Ketoconazole
- Pumpkin seed oil
And strengthening & moisturizing ingredients:
- Biotin
- Keratin
- Coconut oil
- Argan oil
Other ingredients with less research but potentially beneficial effects include green tea extract, tea tree oil, and rosemary extract.
For those with dry or curly hair, opt for a sulfate-free shampoo to avoid potential drying effects.
Read this: Top 7 Hair Serums For Colored Hair To Buy In 2025
How to use DHT-blocking shampoos?
Using a DHT-blocking shampoo is similar to using regular shampoo: lather, rinse, and repeat. Always follow the label's directions, which may include leaving the shampoo on the scalp for a few minutes before rinsing.
It's essential to follow up with a conditioner to maintain hair health. Be cautious when using shampoos containing preservatives, parabens, sulfates, or other potentially irritating ingredients.
Is DHT-blocking shampoo safe?
DHT-blocking shampoos are generally considered safe. However, if you have sensitivities or allergies, perform a patch test before applying the shampoo to your entire scalp by dabbing some shampoo on the inside of your wrist and waiting 24 hours for any signs of irritation.
Be aware that even natural ingredients can cause irritation or allergic reactions. Opt for formulas without harsh chemicals and those free of sulfates and parabens.
When to seek medical advice?
Hair loss can result from various factors, including age, stress, hormones, illness, infections, and medications. Seek advice from a medical professional if you're concerned about hair loss, especially if it's sudden, patchy, or involves body hair, as this may indicate an underlying medical condition requiring diagnosis and treatment.
Also, consult a doctor if you have other symptoms along with hair loss, such as itching, burning, or pain, or if hair loss affects your quality of life.
Frequently Asked Questions
Do DHT-blocking shampoos really work?
DHT-blocking shampoos can be effective in enhancing the appearance of thinning hair caused by male pattern baldness. Consistent use is essential, and it may take months or even a year to see full results. Combining a DHT-blocking shampoo with a prescription treatment plan may yield better results if recommended by your doctor.
How long does it take to see results from DHT-blocking shampoos?
It typically takes 3 to 6 months of consistent use to see results from DHT-blocking shampoos. In the first 4-8 weeks, you may notice reduced shedding and a healthier scalp.
After 3-4 months, hair thinning may slow, and baby hairs might appear. By 6 months, regrowth and thicker hair are more noticeable. To get the best results, use the shampoo regularly, massage it into your scalp, and be patient, as hair regrowth takes time.
What can you do to prevent DHT hair loss?
Consult your doctor about preventative treatments like minoxidil, finasteride, or hair transplant procedures.
You can try eating DHT blocking foods or other topical DHT blockers like finasteride, saw palmetto and more.
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